Therapeutic aptamers
نویسندگان
چکیده
منابع مشابه
Therapeutic Aptamers March On
“Nothing in biology makes sense except in the light of evolution” declared biologist Theodosius Dobzhansky in his seminal 1973 essay.1 This sentiment extends to aptamers, the topic highlighted in our special issue of Molecular Therapy—Nucleic Acids. Aptamers are short single-stranded oligonucleotides that can bind with high affinity and specificity to target molecules, and which are derived thr...
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Aptamers, composed of single-stranded DNA or RNA oligonucleotides that interact with target molecules through a specific three-dimensional structure, are selected from pools of combinatorial oligonucleotide libraries. With their high specificity and affinity for target proteins, ease of synthesis and modification, and low immunogenicity and toxicity, aptamers are considered to be attractive mol...
متن کاملRNA aptamers and their therapeutic and diagnostic applications.
RNA Aptamers refer to RNA oligonulceotides that are capable of binding to specific targets with high affinity and specificity. Through a process called Systematic Evolution of Ligands by EXponential enrichment (SELEX), a number of RNA aptamers have been identified against various targets including organic compounds, nucleotides, proteins and even whole cells and organisms. RNA aptamers have pro...
متن کاملChemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss method...
متن کاملMolecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers
Monoclonal antibodies are the dominant agents used in inhibition of biological target molecules for disease therapeutics, but there are concerns of immunogenicity, production, cost and stability. Oligonucleotide aptamers have comparable affinity and specificity to targets with monoclonal antibodies whilst they have minimal immunogenicity, high production, low cost and high stability, thus are p...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2016
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.147.362